Bay Area COVID patients flag ‘Paxlovid rebound’ after taking antiviral treatment

Bay Area COVID patients flag ‘Paxlovid rebound’ after taking antiviral treatment

When Berkeley resident Myriam Misrach tested positive for the coronavirus last month, she started taking the COVID antiviral pill Paxlovid the same day. Over the five-day course of treatment, her cough and shortness of breath mostly faded, but a couple days after taking the final pill, her symptoms came roaring back.

For 48 hours thereafter, she also had a fever, headache, nausea, runny nose and lost her sense of taste, she said. And she once again tested positive for the virus — despite having tested negative and feeling much better just a few days prior.

“I had everything in the book,” said Misrach, 66, who is vaccinated and boosted. “It was not at all a mild case.”

Misrach continued testing positive for two weeks after that and today is still coughing, though the other symptoms have subsided. What was even more puzzling, she said, was that her husband had also just taken Paxlovid and for him, it “worked beautifully” — he started feeling better almost immediately and stayed that way, though he too tested positive after initially testing negative.

“I’m not blaming Paxlovid but I think they need to study it more,” she said.


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